The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 26, 2005
Filed:
Jun. 25, 2001
Damir Janigro, Cleveland Heights, OH (US);
Marc Mayberg, Chagrin Falls, OH (US);
Gene Barnett, Gates Mills, OH (US);
Damir Janigro, Cleveland Heights, OH (US);
Marc Mayberg, Chagrin Falls, OH (US);
Gene Barnett, Gates Mills, OH (US);
The Cleveland Clinic Foundation, Cleveland, OH (US);
Abstract
The present invention relates generally to a peripheral marker or marker of blood brain barrier integrity and methods of using them in the diagnosis, prognosis, and treatment of a variety of diseases. The preferred embodiments of the present invention relate to methods, compositions, kits, and assays useful in determining the integrity or permeability of a blood brain barrier. The various embodiments of the present invention can be used to identify subjects at risk for developing a disease associated with increased permeability of the blood brain barrier, as well as to provide insight on the ability of an agent or agents to pass the blood brain barrier. Preferably, increased levels of S100β protein are used alone or in combination with other markers of diseased state in order to diagnose and prognosticate permeability of the BBB.