The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 19, 2005
Filed:
May. 30, 2001
Kazunori Kataoka, Tokyo, JP;
Yukio Nagasaki, Ibaraki, JP;
Naoya Shibata, Chiba, JP;
Nobuhiro Hoshino, Tokyo, JP;
Kazunori Kataoka, Tokyo, JP;
Yukio Nagasaki, Ibaraki, JP;
Naoya Shibata, Chiba, JP;
Nobuhiro Hoshino, Tokyo, JP;
Mitsubishi Kagaku Iatron, Inc., Tokyo, JP;
Nanocarrier Co., Ltd., Chiba, JP;
Abstract
A core-shell particle including a signal-generating substance therein, wherein the core-shell particle consists of (1) a core portion substantially made of a water-insoluble polymer compound; and (2) a shell portion substantially made of a water-soluble polymer compound having a reactive functional group, and covering a surface of the core portion in the manner of bristles of a brush; and the core portion and the shell portion are, as a whole, a block copolymer of a water-insoluble polymer and a water-soluble polymer, characterized in that the signal-generating substance is included in the core portion, is disclosed, and a process for producing the same is also disclosed. The core-shell particle including a signal-generating substance therein is useful as a labeling substance in which neither radioisotopes having handling restrictions nor unstable enzymes are required, a high sensitivity superior to fluorescent substances is achieved, and nonspecific absorption does not occur.