The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 12, 2005
Filed:
Mar. 02, 2001
Stefan Hildbrand, Riehen, CH;
Thomas Ruppen, Naters, CH;
Dario Veghini, Brig, CH;
Lonza AG, Basel, CH;
Abstract
β-alaninamides of the general formulaWherein Ris hydrogen or Calkyl which is unsubstituted or substituted with hyroxy, amino, carboxy, carbamoyl, methylmercapto, guanidino, unsubstituted or substituted aryl or heteroaryl, and Ris hydrogen, or Rand Rtogether form a group of the formula —(CH)— where n is 3 or 4, and Ris hydrogen, a negative charge compensated by an equivalent of an inorganic or organic cation or is Calkyl, are prepared, without using an amino-protective group, by reacting the corresponding α-amino acid or the corresponding α-amino acid ester with a cyanoacetic ester to give a cyanoacetamide and by subsequent catalytic hydrogenation. The method is particularly suitable for preparing carnosine (β-alanyl-L-histidine, R=imidazol-4-yl-methyl, R=R=H), a naturally occurring dipeptide which used as a dietary supplement with antioxidative action.