The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 12, 2005
Filed:
Apr. 07, 2000
J. Peter Klein, Vashon, WA (US);
Stephen J. Klaus, New York, NY (US);
Anil M. Kumar, Puyallup, WA (US);
Baoqing Gong, Shoreline, WA (US);
J. Peter Klein, Vashon, WA (US);
Stephen J. Klaus, New York, NY (US);
Anil M. Kumar, Puyallup, WA (US);
Baoqing Gong, Shoreline, WA (US);
Cell Therapeutics, Inc., Seattle, WA (US);
Abstract
Novel heterocyclic compounds having a six membered ring structure fused to a five membered ring structure are found to be useful for the treatment and prevention of symptoms or manifestations associated with disorders affected by Interleukin-12 ('IL-12') intracellular signaling, such as, for example, Th1 cell-mediated disorders. The therapeutic compounds, pharmaceutically acceptable derivatives (e.g., resolved enantiomers, diastereomers, tautomers, salts and solvates thereof) or prodrugs thereof, have the following general formula:Each X, Y and Z are independently selected from a member of the group consisting of C(R), N, N(R) and S. Each R, Rand Ris substituted or unsubstituted and is independently selected from a member of the group consisting of hydrogen, halo, oxo, Calkyl, Chydroxyalkyl, Cthioalkyl, Calkylamino, Calkylaminoalkyl, Caminoalkyl, Caminoalkoxyalkenyl, Caminoalkoxyalkynyl, Cdiaminoalkyl, Ctriaminoalkyl, Ctetraaminoalkyl, Caminotrialkoxyamino, Calkylamido, Calkylamidoalkyl, Camidoalkyl, Cacetamidoalkyl, Calkenyl, Calkynyl, Calkoxyl, Calkoxyalkyl, and Cdialkoxyalkyl.