The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 12, 2005
Filed:
Dec. 22, 1999
Wolfgang Fritzsche, Jena, DE;
Andrea Czaki, Camburg, DE;
Johann Michael Köhler, Golmsdorf, DE;
Antje Wiegand, Jena, DE;
Louis Oosting, Groningen, NL;
Frederik Schut, Groningen, NL;
Paris Som Tjwan Tan, Haren, NL;
Wolfgang Fritzsche, Jena, DE;
Andrea Czaki, Camburg, DE;
Johann Michael Köhler, Golmsdorf, DE;
Antje Wiegand, Jena, DE;
Louis Oosting, Groningen, NL;
Frederik Schut, Groningen, NL;
Paris Som Tjwan Tan, Haren, NL;
Genetrix B.V., Haren, NL;
Abstract
The invention relates to an affinity sensor for detecting specific molecular binding events, for use in the field of molecular biology, e.g., in medical diagnostics, especially in biosensor technology or in DNA microarreay tests. The aim of the invention is to provide an affinity sensor of this type for rapidity, sensitively, specifically, economically and routinely detecting the presence of molecules, especially bioactive molecules, and to provide special applications for an affinity sensor of this type. To this end, the affinity sensor consists of a support substrate which is provided with at least two electrodes. The electrodes are situated equidistantly from each other and cover an area on both sides, at least this area being provided for receiving immobilized specific binding partners which are capable of coupling complementary corresponding binding partners directly or with other specific binding molecules. The area is established with a minimum width b, in such a way that at least one complementary corresponding binding partner which is provided with an electroconductive particle can be received in the area in such a way as to guarantee the possibility of a tunnel-type contact junction forming between the particle and the electrodes in each case. The affinity sensor is used for biomonitoring.