The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 05, 2005
Filed:
Apr. 23, 2001
Marston Manthorpe, San Diego, CA (US);
Jukka Hartikka, San Diego, CA (US);
Loretta Sukhu, San Diego, CA (US);
Jennifer Meek, San Diego, CA (US);
Marston Manthorpe, San Diego, CA (US);
Jukka Hartikka, San Diego, CA (US);
Loretta Sukhu, San Diego, CA (US);
Jennifer Meek, San Diego, CA (US);
Vical Incorporated, San Diego, CA (US);
Abstract
The present invention relates to pharmaceutical compositions and methods to improve expression of exogenous polypeptides into vertebrate cells in vivo, utilizing delivery of polynucleotides encoding such polypeptides. More particularly, the present invention provides the use of salts, in particular sodium and potassium salts of phosphate, in aqueous solution, and auxiliary agents, in particular detergents and surfactants, in pharmaceutical compositions and methods useful for direct polynucleotide-based polypeptide delivery into the cells of vertebrates.