The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 05, 2005
Filed:
May. 31, 2001
Applicants:
James N. Higginbotham, Ames, IA (US);
Charles J. Link, Des Moines, IA (US);
William J. Ramsey, Ames, IA (US);
Inventors:
James N. Higginbotham, Ames, IA (US);
Charles J. Link, Des Moines, IA (US);
William J. Ramsey, Ames, IA (US);
Assignee:
Human Gene Therapy Research Institute, Des Moines, IA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N015/861 ; C12N015/63 ; C12N015/64 ; C12N005/10 ; C07H021/04 ;
U.S. Cl.
CPC ...
Abstract
The invention includes a viral vector method and composition comprising transcomplementary replication incompetent viral vectors, preferably adenoviral vectors, which are cotransformed to a recipient cell. The two vectors complement each other and thus allow viral replication, in a synergistic combination which enhances both gene delivery and gene expression of genetic sequences contained within the vector.