The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 05, 2005
Filed:
Mar. 10, 1995
Michael Dörschug, Bochum, DE;
Paul Habermann, Eppstein/Taunus, DE;
Gerhard Seipke, Hofheim am Taunus, DE;
Eugen Uhlmann, Glashütten/Taunus, DE;
Michael Dörschug, Bochum, DE;
Paul Habermann, Eppstein/Taunus, DE;
Gerhard Seipke, Hofheim am Taunus, DE;
Eugen Uhlmann, Glashütten/Taunus, DE;
Hoechst Aktiengesellschaft, Frankfurt am Main, DE;
Abstract
A mini-proinsulin, in which the amino acid Arg bridges the A and the B chain instead of the C chain, shows insulin activity and is suitable for the preparation of pharmaceuticals for the treatment of diabetes mellitus. It can furthermore be converted into an insulin derivative simply using trypsin, the B chain of which is lengthened by Arg. This can be converted into insulin using carboxypeptidase B. Advantageously, however, the mini-proinsulin can also be converted to insulin directly in a one-pot process.