The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 29, 2005
Filed:
May. 02, 2000
Zorica Maru{hacek Over (S)}ic-i{hacek Over (S)}tuk, Samobor, HR;
Nedjelko Kujund{hacek Over (Z)}ić, Zagreb, HR;
Gabrijela Kobrehel, Zagreb, HR;
Stjepan Mutak, Zagreb, HR;
Nata{hacek Over (S)}a Mar{hacek Over (S)}ić, Zagreb, HR;
Zorica Maru{hacek over (s)}ic-I{hacek over (s)}tuk, Samobor, HR;
Nedjelko Kujund{hacek over (z)}ić, Zagreb, HR;
Gabrijela Kobrehel, Zagreb, HR;
Stjepan Mutak, Zagreb, HR;
Nata{hacek over (s)}a Mar{hacek over (s)}ić, Zagreb, HR;
PLIVA farmaceutska industrija dionicko drustvo, Zagreb, HR;
Abstract
The invention relates to halo derivatives of 9a-N-(N'-arylcarbamoyl)- and 9a-N-(N′-arylthiocarbamoyl)-9-deoxo-9a-aza-9a-homoerythromycin A of the general formula (I)wherein R has the meaning of a substituted aryl group of the formula (II)wherein substituents a, b, c, d and e are the same or different and at least one of them has the meaning of halo, a (C-C)haloalkyl or a (C-C)haloalkoxy group, whereas the remaining ones have the meaning of hydrogen, halo, a (C-C)alkyl or a (C-C)alkoxy group, and X has the meaning of oxygen or sulfur, and pharmaceutically acceptable addition salts thereof with inorganic or organic acids, to a process for their preparation, to a process for the preparation of pharmaceutical compositions comprising them and to the use of these pharmaceutical compositions for the treatment or prevention of bacterial infections.