The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 29, 2005
Filed:
Jun. 23, 1999
Peter Castric, Pittsburgh, PA (US);
Alan S. Cross, Chevy Chase, MD (US);
Jerald C. Sadoff, Washington, DC (US);
Peter Castric, Pittsburgh, PA (US);
Alan S. Cross, Chevy Chase, MD (US);
Jerald C. Sadoff, Washington, DC (US);
The United States of America as represented by the Secretary of the Army, Washington, DC (US);
Abstract
The present invention relates to a broadly reactive vaccine against Gram-negative bacteria which is composed of a biological glycan-pilus conjugate. The conjugate core is a common pilus type to which is attached the glycan of choice in vivo. Pooling of these bioconjugates produces a multivalent vaccine. These pili give high bronchial titers when delivered by the intranasal route. Mice vaccinated with pure glycosylatedstrain 1244 pili in this manner are protected against respiratory challenge withstrain 1244. The present invention further relates to a DNA and amino acid sequence of a new gene, pilO, which is capable of glycosylating pilin of Gram-negative bacteria and uses thereof.