The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 22, 2005

Filed:

Nov. 13, 2003
Applicants:

Verena D. Huebner, Benicia, CA (US);

Xiaodong Lin, Walnut Creek, CA (US);

Ian James, Rowville, AU;

Liya Chen, East Brunswick, NJ (US);

Manoj Desai, Pleasant Hill, CA (US);

Jennifer C. Moore, Emeryville, CA (US);

Beata Krywult, Armadale, AU;

Thayalan Navaratnam, San Leandro, CA (US);

Rajinder Singh, San Francisco, CA (US);

Rob Trainor, Murrumbeena, AU;

Liang Wang, Lafayette, CA (US);

Inventors:

Verena D. Huebner, Benicia, CA (US);

Xiaodong Lin, Walnut Creek, CA (US);

Ian James, Rowville, AU;

Liya Chen, East Brunswick, NJ (US);

Manoj Desai, Pleasant Hill, CA (US);

Jennifer C. Moore, Emeryville, CA (US);

Beata Krywult, Armadale, AU;

Thayalan Navaratnam, San Leandro, CA (US);

Rajinder Singh, San Francisco, CA (US);

Rob Trainor, Murrumbeena, AU;

Liang Wang, Lafayette, CA (US);

Assignee:

Chiron Corporation, Emeryville, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K031/42 ; C07D261/02 ; C07D261/06 ;
U.S. Cl.
CPC ...
Abstract

Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.


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