The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2005
Filed:
Sep. 17, 1999
Svend Havelund, Bagsvaerd, DK;
John Halstrom, Hundested, DK;
Ib Jonassen, Valby, DK;
Asser Sloth Andersen, Frederiksberg, DK;
Jan Markussen, Herlev, DK;
Svend Havelund, Bagsvaerd, DK;
John Halstrom, Hundested, DK;
Ib Jonassen, Valby, DK;
Asser Sloth Andersen, Frederiksberg, DK;
Jan Markussen, Herlev, DK;
Novo Nordisk A/S, Bagsvaerd, DK;
Abstract
The present invention relates to protracted human insulin derivatives in which the A21 and the B3 amino acid residues are, independently, any amino acid residue which can be coded for by the genetic code except Lys, Arg and Cys; Phemay be deleted; the B30 amino acid residue is (a) a non-codable, lipophilic amino acid having from 10 to 24 carbon atoms, in which case an acyl group of a carboxylic acid with up to 5 carbon atoms is bound to the ε-amino group of Lys; or (b) the B30 amino acid residue is deleted or is any amino acid residue which can be coded for by the genetic code except Lys, Arg and Cys, in any of which cases the ε-amino group of Lyshas a lipophilic substituent; and any Zncomplexes thereof with the proviso that when B30 is Thr or Ala and A21 and B3 are both Asn, and Pheis present, then the insulin derivative is always present as a Zncomplex.