The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2005
Filed:
Nov. 13, 2001
Cynthia A. Edwards, Menlo Park, CA (US);
Charles R. Cantor, Del Mar, CA (US);
Beth M. Andrews, Maynard, MA (US);
Lisa M. Turin, Redwood City, CA (US);
Kirk E. Fry, Palo Alto, CA (US);
Cynthia A. Edwards, Menlo Park, CA (US);
Charles R. Cantor, Del Mar, CA (US);
Beth M. Andrews, Maynard, MA (US);
Lisa M. Turin, Redwood City, CA (US);
Kirk E. Fry, Palo Alto, CA (US);
Genelabs Technologies, Inc., Redwood City, CA (US);
Abstract
The present invention defines a DNA: protein-binding assay useful for screening libraries of synthetic or biological compounds for their ability to bind DNA test sequences. The assay is versatile in that any number of test sequences can be tested by placing the test sequence adjacent to a defined protein binding screening sequence. Binding of molecules to these test sequence changes the binding characteristics of the protein molecule to its cognate binding sequence. When such a molecule binds the test sequence the equilibrium of the DNA:protein complexes is disturbed, generating changes in the concentration of free DNA probe. Numerous exemplary target test sequences (SEQ ID NO:1 to SEQ ID NO:600) are set forth. The assay of the present invention is also useful to characterize the preferred binding sequences of any selected DNA-binding molecule.