The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 2005
Filed:
Feb. 18, 2000
Applicants:
Walter Newman, Boston, MA (US);
Dominic Picarella, Sudbury, MA (US);
Dulce Soler, Watertown, MA (US);
Inventors:
Walter Newman, Boston, MA (US);
Dominic Picarella, Sudbury, MA (US);
Dulce Soler, Watertown, MA (US);
Assignee:
Millennium Pharmaceuticals, Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K039/395 ; A61K038/00 ; C07K016/18 ; C07D049/34 ;
U.S. Cl.
CPC ...
Abstract
Biotinylated pharmacologically active agents and complexes containing same are disclosed. In particular, biotinylated-chemokines are described. The complexes further include an anti-biotin antibody that selectively binds to biotin. The complex can be dissociated by contact with free biotin. The complexes are particularly useful for enhancing an immune response to tumor cells and virus-infected cells, in vivo or in vitro.