The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 2005
Filed:
Jan. 27, 1999
Stephen L. Buchwald, Newton, MA (US);
John P. Wolfe, Brighton, MA (US);
Jens Ahman, Sandwich, GB;
Malisa Troutman, Irvington, NY (US);
Michael Palucki, Belle Meade, NJ (US);
Ken Kamikawa, Brookline, MA (US);
Andre Chieffi, Somerville, MA (US);
Stephen L. Buchwald, Newton, MA (US);
John P. Wolfe, Brighton, MA (US);
Jens Ahman, Sandwich, GB;
Malisa Troutman, Irvington, NY (US);
Michael Palucki, Belle Meade, NJ (US);
Ken Kamikawa, Brookline, MA (US);
Andre Chieffi, Somerville, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The present invention provides transition-metal-catalyst-based methods for the arylation and vinylation of activated methyl, methylene, and methine carbons with aryl halides, vinyl halides, and the like. The methods of the invention provide several improvements over existing methods, including the ability to synthesize efficiently and under mild conditions α-aryl and α-vinyl products from a wide range of starting materials, including ketones, esters, hydrazones, and imines. Furthermore, the methods of the invention may be used in an asymmetric sense, i.e. to produce enantiomerically-enriched chiral α-aryl and α-vinyl products.