The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 2005
Filed:
Nov. 06, 2002
Jollie Duaine Godfrey, Jr., Ewing, NJ (US);
John Hynes, Jr., Washington Crossing, PA (US);
Alaric J. Dyckman, Lawrenceville, NJ (US);
Katerina Leftheris, Skillman, NJ (US);
Zhongping Shi, West Windsor, NJ (US);
Stephen T. Wrobleski, Whitehouse Station, NJ (US);
Wendel William Doubleday, Doylestown, PA (US);
John A. Grosso, Princeton Junction, NJ (US);
Jollie Duaine Godfrey, Jr., Ewing, NJ (US);
John Hynes, Jr., Washington Crossing, PA (US);
Alaric J. Dyckman, Lawrenceville, NJ (US);
Katerina Leftheris, Skillman, NJ (US);
Zhongping Shi, West Windsor, NJ (US);
Stephen T. Wrobleski, Whitehouse Station, NJ (US);
Wendel William Doubleday, Doylestown, PA (US);
John A. Grosso, Princeton Junction, NJ (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I):or a pharmaceutically acceptable salt or solvate thereof, wherein Rthrough Rand Z are as described in the specification. The methods according to the invention utilize an amination process, in which a pyrrole is reacted with a haloamine, preferably chloramine. This step is followed by cyclization to form the pyrrolotriazine core.