Il-5 inhibiting 6-azauracil derivatives

Abstract

The present invention is concerned with the compounds of formulathe N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, p and q are 0, 1, 2, 3 or 4 and q is also 5; X is O, S, NRor a direct bond; Ris hydrogen, hydroxy, halo, optionally substituted amino, optionally substituted Calkyl, Calkyloxy, Ccycloalkyl or aryl; Ris aryl, Het, Ccycloalkyl, optionally substituted Calkyl; and if X is O, S or NR, then Rmay also be a carbonyl or thiocarbonyl linked substituent; Ris hydrogen or Calkyl; Rand Rindependently are optionally substituted Calkyl, halo, hydroxy, mercapto, Calkyloxy, Cakylthio, Calkylcarbonyloxy, aryl, cyano, nitro, Het, Ror NRR; Ris substituted sulfonyl or sulfinyl; Rand Rare hydrogen, optionally substituted Calkyl, aryl, a carbonyl or thiocarbonyl linked substituent, Ccycloalkyl, Hetand R; Rand Rare each independently selected from hydrogen, optionally substituted Calkyl, phenyl, a carbonyl or thiocarbonyl linked substituent, Ccycloalkyl, Hetand R; Ris hydroxy, mercapto, cyano, nitro, halo, trihalomethyl, Calkyloxy, carboxyl, Calkyloxycarbonyl, trihaloCalkylsulfonyloxy, R, NRR, C(═O)NRR, aryl, aryloxy, arylcarbonyl, Ccycloalkyl, Ccycloalkyloxy, phthalimide-2-yl, Hetand C(═O)Het; Rand Rare each independently selected from hydrogen, optionally substituted Calkyl, phenyl, a carbonyl or thiocarbonyl linked substituent, Ccycloalkyl and R; aryl is optionally substituted phenyl; Het, Hetand Hetare optionally substituted heterocycles; to processes for their preparation and compositions comprising them. It further relates to their use as a medicine.