The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2005
Filed:
Apr. 14, 2000
Igor Splawski, Alston, MA (US);
Mark T. Keating, Brookline, MA (US);
Geoffrey W. Abbott, New Haven, CT (US);
Federico Sesti, New Haven, CT (US);
Steve A. N. Goldstein, Guilford, CT (US);
Igor Splawski, Alston, MA (US);
Mark T. Keating, Brookline, MA (US);
Geoffrey W. Abbott, New Haven, CT (US);
Federico Sesti, New Haven, CT (US);
Steve A. N. Goldstein, Guilford, CT (US);
University of Utah Research Foundation, Salt Lake City, UT (US);
Yale University, New Haven, CT (US);
Abstract
The present invention is directed to genes and gene products related to Min-K which form ion channels and to a process for diagnosis of ion channel disorders, including long QT syndrome (LQT). For example, KCNE2 forms Ipotassium channels and is associated with LQT. LQT is diagnosed in accordance with the present invention by analyzing the DNA sequence of KCNE2 of an individual to be tested and comparing the respective DNA sequence to the known DNA sequence of a normal KCNE2 gene. Alternatively, these MinK-related genes of an individual to be tested can be screened for mutations which cause ion channel disorders, including LQT. Prediction of ion channel disorders, including LQT, will enable practitioners to prevent the disorders using existing medical therapy. This invention is further directed to the discovery that the HERG and KCNE2 (also known as MiRP1) proteins coassemble to form a cardiac Ipotassium channel.