The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2005
Filed:
Aug. 22, 2000
Michael J. May, New Haven, CT (US);
Sankar Ghosh, Madison, CT (US);
Michael J. May, New Haven, CT (US);
Sankar Ghosh, Madison, CT (US);
Yale University, New Haven, CT (US);
Abstract
The invention includes compositions and methods for the selective inhibition of cytokine-mediated NF-κB activation by blocking the interaction of NEMO with IκB kinase-β (IKKβ) at the NEMO binding domain (NBD). The blockade of IKKβ-NEMO interaction resulting in inhibition of IKKβ kinase activity and subsequent decreased phosphorylation of IκB. Phosphorylation of IκB being an integral step in cytokine-mediated NF-κB activation. The invention further includes methods for screening for agents capable of interacting at the NBD and therapeutic uses for such agents in pathological disorders caused by dysregulation of NF-κB activation.