The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2005
Filed:
Dec. 12, 2001
Raymond P. Zinkowski, Northbrook, IL (US);
Daniel J. Kerkman, Lake Villa, IL (US);
Russell E. Kohnken, Skokie, IL (US);
John F. Debernardis, Lindenhurst, IL (US);
Peter Davies, Rye, NY (US);
Raymond P. Zinkowski, Northbrook, IL (US);
Daniel J. Kerkman, Lake Villa, IL (US);
Russell E. Kohnken, Skokie, IL (US);
John F. DeBernardis, Lindenhurst, IL (US);
Peter Davies, Rye, NY (US);
Molecular Geriatrics Corporation, Vernon Hills, IL (US);
Abstract
The invention relates, among other things, a preparation comprising Alzheimer's disease antigen (A68), as well as methods of obtaining this purified antigen, and methods of using this purified antigen, for instance, for diagnosing Alzheimer's disease and for detecting human autoantibodies to the Alzheimer disease antigen. The antigen preparation according to the invention is purified in that it is substantially free of immunoglobulin G. The invention further relates to methods of making Alzheimer disease antigens that can be used instead of or along with the A68 antigen preparation (e.g., for diagnosing AD), such as recombinant human tau, tau isolated from various species including human, and phosphorylated recombinant human tau or isolated tau, as well as A68 anti-idiotypic antibodies.