The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 2005
Filed:
Jun. 25, 1997
Thuong Nguyen, Vienne en Val, FR;
Ulysse Asseline, Orléans, FR;
Hong Khanh Nguyen, Vienne en Val, FR;
Maurice Durand, Orléans, FR;
Jean-claude Maurizot, Orléans, FR;
Daniel Dupret, Haguenau, FR;
Edwige Bonfils, Strasbourg, FR;
Thuong Nguyen, Vienne en Val, FR;
Ulysse Asseline, Orléans, FR;
Hong Khanh Nguyen, Vienne en Val, FR;
Maurice Durand, Orléans, FR;
Jean-Claude Maurizot, Orléans, FR;
Daniel Dupret, Haguenau, FR;
Edwige Bonfils, Strasbourg, FR;
Appligene-Oncor S.A., Illkirch Cedex, FR;
Abstract
The invention discloses a method for producing a hybridization complex whose stability is substantially independent of the base composition of two hybridized nucleic acid molecules, consisting in contacting a first nucleic acid molecule with a second nucleic acid molecule under conditions enabling the formation of a specific hybridization complex. The invention is characterized in that at least one of the four types of bases contained in the sequence of the first and/or of the second nucleic acid molecule is a modified base having pairing properties close to those of the natural base it replaces, such that at least one of the two types of the base pair contained in the composition of the complex comprises a modified base and in that the totality of the base pairs contained in the composition of the said complex has a like stability.