The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2005
Filed:
Jul. 03, 2003
Ronit Yahalomi, Kiryat Bialik, IL;
Evgeny Shapiro, Haifa, IL;
Ben-zion Dolitzky, Petach Tiqva, IL;
Yigael Gozlan, Ramot Sapir, IL;
Ronit Yahalomi, Kiryat Bialik, IL;
Evgeny Shapiro, Haifa, IL;
Ben-Zion Dolitzky, Petach Tiqva, IL;
Yigael Gozlan, Ramot Sapir, IL;
Teva Pharmaceuticals Industries Ltd., Petah Tiqva, IL;
Abstract
Provided is a process for preparation of an intermediate in the synthesis of nateglinide. Trans-4-isopropylcyclohexane acid chloride is formed by reacting 4-isopropylcyclohexanecarboxyl acid with thionyl chloride in the presence of an effective amount of an organic amide. Also provided are processes for preparation of nateglinide by acylation of a suitable salt of D-phenylalanine with trans-4-isopropylcyclohexane acid chloride in both a single and a two phase system, and in water free of a co-solvent.
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