The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2005
Filed:
Apr. 26, 2001
Pierre Chambon, Blaesheim, FR;
Hinrich Gronemeyer, Oberkirch, DE;
Johannes Voegel, Strasbourg, FR;
Yves Lutz, Strasbourg, FR;
Pierre Chambon, Blaesheim, FR;
Hinrich Gronemeyer, Oberkirch, DE;
Johannes Voegel, Strasbourg, FR;
Yves Lutz, Strasbourg, FR;
Institut National de la Sante et de la Recherche Medicale, Paris, FR;
Centre National de la Recherche Scientifique, Paris, FR;
Universite Louis Pasteur, Strasbourg, FR;
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
The present invention concerns a nuclear receptor (NR) transcriptional mediator. More specifically, isolated nucleic acid molecules are provided encoding transcriptional intermediary factor-2 (TIF2). Recombinant methods for making TIF2 polypeptides are also provided as are TIF2 antibodies. Screening methods are also provided for identifying agonists and antagonists of the activation function AF-2 of nuclear receptors, for identifying agonists and antagonists of the AD1 activation domain activity of TIF2, and for identifying agonists and antagonists of the AD2 activation domain activity of TIF2.