The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 01, 2005

Filed:

Jan. 03, 2001
Applicants:

Fumitaka Ito, Chita-Gun, JP;

Hirohide Noguchi, Chita-Gun, JP;

Yoriko Ohashi, Chita-Gun, JP;

Hirohisa Shimokawa, Chita-Gun, JP;

Inventors:

Fumitaka Ito, Chita-Gun, JP;

Hirohide Noguchi, Chita-Gun, JP;

Yoriko Ohashi, Chita-Gun, JP;

Hirohisa Shimokawa, Chita-Gun, JP;

Assignee:

Pfizer, Inc., New York, NY (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D487/08 ; C07D401/14 ; C07D403/14 ; C07D401/04 ; A61K031/496 ;
U.S. Cl.
CPC ...
Abstract

A compound of the formula:or a pharmaceutically acceptable salt thereof, wherein Ris unsubstituted, mono-, di- or tri-substituted (C-C)cycloalkyl or (C-C)cycloalkenyl or the like, A is unsubstituted (C-C)alkyl or (C-C)alkenyl, hydroxy-(C-C)alkyl, (C-C)alkoxy-(C═O), or unsubstituted, mono-, di- or tri-substituted aryl, or aromatic-heterocyclic or the like, M is a covalent bond O, S, NH or the like, Y is 4- to 12-membered bicyclic-carbocyclic rings or 4- to 12-membered bicyclic-heterocyclic rings, or 5- to 17 membered spirocarbocyclic rings or 5- to 17-membered spiroheterocyclic rings or the like, Z, Z, Zand Zare hydrogen or the like, is disclosed. These compounds have ORL-receptor agonist activity, and are thus useful as analgesics or the like in mammalian subjects.


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