The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2005
Filed:
Apr. 18, 2001
John A. Drewe, Carlsbad, CA (US);
Sui Xiong Cai, San Diego, CA (US);
Emma Jane Shelton, Menlo Park, CA (US);
Joane Litvak, Oakland, CA (US);
David Sperandio, Mountain View, CA (US);
Jeffrey R. Spencer, South San Francisco, CA (US);
Martin Sendzik, San Mateo, CA (US);
John A. Drewe, Carlsbad, CA (US);
Sui Xiong Cai, San Diego, CA (US);
Emma Jane Shelton, Menlo Park, CA (US);
Joane Litvak, Oakland, CA (US);
David Sperandio, Mountain View, CA (US);
Jeffrey R. Spencer, South San Francisco, CA (US);
Martin Sendzik, San Mateo, CA (US);
Cytovia, Inc., San Diego, CA (US);
Abstract
The present invention is directed to substituted 1,4-thiazepine and analogs thereof, represented by the general Formula I:wherein the dashed lines, A, A, A, Xand Rare defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of capases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.