The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2005
Filed:
Nov. 24, 1999
Applicant:
Stephen B. Liggett, Cincinnati, OH (US);
Inventor:
Stephen B. Liggett, Cincinnati, OH (US);
Assignees:
Genaissance Pharmaceuticals, Inc., New Haven, CT (US);
University of Cincinnati, Cincinnati, OH (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q001/68 ; C12P019/34 ; C07H021/04 ;
U.S. Cl.
CPC ...
Abstract
A novel polymorphic site in the 5' leader cistron of the β-adrenergic receptor (βAR) gene is disclosed. The polymorphisms present at this site result in different levels of inhibition of translation of βAR mRNA. Compositions and methods for genotyping this polymorphic site as disclosed. In addition, methods for using this genotype information are disclosed, including predicting genetic predisposition to a disease modified by βAR expression and predicting a patient's bronchodilating response to β-agonists.