The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2005
Filed:
Apr. 07, 1998
Elaine I. Tuomanen, Germantown, TN (US);
Theresa M. Wizemann, North Potamac, MD (US);
H. Robert Masure, Germantown, TN (US);
Leslie Sydnor Johnson, Germantown, MD (US);
Scott Koenig, Rockville, MD (US);
Elaine I. Tuomanen, Germantown, TN (US);
Theresa M. Wizemann, North Potamac, MD (US);
H. Robert Masure, Germantown, TN (US);
Leslie Sydnor Johnson, Germantown, MD (US);
Scott Koenig, Rockville, MD (US);
St. Jude Children's Research Hospital, Memphis, TN (US);
MedImmune, Inc., Gaithersburg, MD (US);
Abstract
This invention provides an isolated polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate in which the amino acid sequence is set forth in any of SEQ ID NOS: 1, 3-7, or 9-11, including fragments, mutants, variants, analogs, or derivatives, thereof. Also, this invention provides a isolated polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate, wherein the amino acid is set forth in SEQ ID NO 24, wherein the polypeptide retains its native tertiary structure and methods of preparation. This invention provides an isolated polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate, wherein the polypeptide has lectin activity and does not bind to choline. This invention provides an isolated immunogenic polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate. This invention provides an isolated nucleic acid encoding a polypeptide comprising an amino acid sequence of a N-terminal choline binding protein A truncate. Lastly, this invention provides pharmaceutical compositions, vaccines, and diagnostic and therapeutic methods of use.