The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2005
Filed:
Aug. 27, 2003
David B. Reitz, Chesterfield, MO (US);
Robert E. Manning, St. Louis, MO (US);
David B. Reitz, Chesterfield, MO (US);
Robert E. Manning, St. Louis, MO (US);
G.D. Searle & Co., Chicago, IL (US);
Abstract
A class of 1-phenyl imidazol-2-one biphenylmethyl compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formulawherein each of R, Rand Ris independently selected from hydrido, alkyl, alkoxy, cyano, halo, hydroxy, carboxyl, alkoxycarbonyl, formyl and acetyl; alkylcarbonyl and haloalkylcarbonyl; with the proviso that at least one of R, Rand Rmust be a substituent other than hydrido, and with the further proviso that when each of Rand Ris hydrido, then Rcannot be chloro; wherein Ris hydrido; wherein Ris alkyl; and wherein Ris tetrazolyl; or a stereoisomer or a tautomer thereof or a pharmaceutically-acceptable salt thereof. These compounds are particularly useful in treatment or control of hypertension and congestive heart failure.