The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2005
Filed:
Jun. 08, 1999
David M. Marquis, Encinitas, CA (US);
Gilbert M. Iverson, Del Mar, CA (US);
Edward J. Victoria, San Diego, CA (US);
David S. Jones, San Diego, CA (US);
Matthew D. Linnik, San Diego, CA (US);
David M. Marquis, Encinitas, CA (US);
Gilbert M. Iverson, Del Mar, CA (US);
Edward J. Victoria, San Diego, CA (US);
David S. Jones, San Diego, CA (US);
Matthew D. Linnik, San Diego, CA (US);
La Jolla Pharmaceutical Co., San Diego, CA (US);
Abstract
The present invention provides domain 1 βGPI polypeptides, polynucleotides encoding these polypeptides, mimetics of these polypeptides, and methods using domain 1 βGPI polypeptides and mimetics. Domain 1 of βGPI has been shown to bind to anti-cardiolipin (βGPI-dependent antiphospholipid) antibodies, which are associated with several pathologies, such as thrombosis and fetal loss. The domain 1 βGPI polypeptides may be used to detect βGPI-dependent antiphospholipid antibodies in a sample. The invention further provides methods of inducing tolerance using these domain 1 βGPI polypeptides.