The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2005
Filed:
Mar. 13, 2002
Linus S. Lin, Westfield, NJ (US);
George Doherty, Princeton, NJ (US);
Shrenik K. Shah, Metuchen, NJ (US);
Linda L. Chang, Wayne, NJ (US);
William K. Hagmann, Westfield, NJ (US);
Richard A. Mumford, Red Bank, NJ (US);
Linus S. Lin, Westfield, NJ (US);
George Doherty, Princeton, NJ (US);
Shrenik K. Shah, Metuchen, NJ (US);
Linda L. Chang, Wayne, NJ (US);
William K. Hagmann, Westfield, NJ (US);
Richard A. Mumford, Red Bank, NJ (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
Compounds of Formula I are antagonists of VLA-4 and/or alpha4/beta7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of AIDS-related dementia, allergic conjunctivitis, allergic rhinitis, Alzheimer's disease, asthma, atherosclerosis, autologous bone marrow transplantation, certain types of toxic and immune-based nephritis, contact dermal hypersensitivity, inflammatory bowel disease including ulcerative colitis and Crohn's disease, inflammatory lung diseases, inflammatory sequelae of viral infections, meningitis, multiple sclerosis, multiple myeloma, myocarditis, organ transplantation, psoriasis, pulmonary fibrosis, restenosis, retinitis, rheumatoid arthritis, septic arthritis, stroke, tumor metastasis, uveititis, and type I diabetes.