The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2005
Filed:
Nov. 22, 1999
Paul B. Mccray, Jr., Iowa City, IA (US);
Guoshun Wang, Iowa City, IA (US);
Beverly Davidson, North Liberty, IA (US);
Mordechai Bodner, San Diego, CA (US);
Steven M. Herrmann, San Diego, CA (US);
Douglas J. Jolly, Encinitas, CA (US);
Paul B. McCray, Jr., Iowa City, IA (US);
Guoshun Wang, Iowa City, IA (US);
Beverly Davidson, North Liberty, IA (US);
Mordechai Bodner, San Diego, CA (US);
Steven M. Herrmann, San Diego, CA (US);
Douglas J. Jolly, Encinitas, CA (US);
The University of Iowa Research Foundation, Iowa City, IA (US);
Chiron Corporation, Emeryville, CA (US);
Abstract
The present invention involves methods and compositions for increasing the susceptibility of target cells to transduction by gene transfer vectors. Specifically, it is proposed that increasing intracellular permeability in epithelial tissue increases the percentage of input vector that will transduce that target tissue. Specific examples show that receptors for retrovirus are preferentially accessible on the basolateral surface of airway epithelia, and permeabilizing such tissues results in greater infection with retrovirus. This has important implications in gene therapy, for example, to treat cystic fibrosis with the CFTR gene.