The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2005
Filed:
Sep. 12, 2000
Controlling availability or activity of proteins by use of protease inhibitors or receptor fragments
Gerardus Jacobus Antonius Maria Strous, Haaften, NL;
Petrus J. M. Van Kerkhof, Beneden Leeuwen, NL;
Roland Marinus Theodorus Govers, Utrecht, NL;
Gerardus Jacobus Antonius Maria Strous, Haaften, NL;
Petrus J. M. Van Kerkhof, Beneden Leeuwen, NL;
Roland Marinus Theodorus Govers, Utrecht, NL;
Universiteit Utrecht, Utrecht, NL;
Abstract
The invention relates to the field of proteins, more specifically to those proteins that are located on the surface of the cell. The invention, amongst others, provides an inhibitor or pharmaceutical composition that is capable of inhibiting down-regulation of a cell surface receptor. The invention provides a method to control or up-regulate hormone activity by using inhibitors or reagents that modify down-regulation of a protein. The invention further provides a method to control or up-regulate protein activity wherein ligand-induced receptor uptake and/or degradation by endocytosis of a receptor is inhibited, preferably by inhibiting the ubiquitin/proteasome system.