The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 15, 2005

Filed:

Apr. 14, 2000
Applicants:

Guus Hateboer, Heemstede, NL;

Karina Cornelia Verhulst, Leiden, NL;

Govert Johan Schouten, Leiderdorp, NL;

Alphonsus Gerardus Uytdehaag, DeBilt, NL;

Abraham Bout, Moerkapelle, NL;

Inventors:

Guus Hateboer, Heemstede, NL;

Karina Cornelia Verhulst, Leiden, NL;

Govert Johan Schouten, Leiderdorp, NL;

Alphonsus Gerardus Uytdehaag, DeBilt, NL;

Abraham Bout, Moerkapelle, NL;

Assignee:

Crucell Holland B.V., Leiden, NL;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N005/00 ; C12N015/63 ; C12N021/04 ; C12P021/06 ;
U.S. Cl.
CPC ...
Abstract

Methods and compositions for the production of recombinant proteins in a human cell line. The methods and positions are particularly useful for generating stable expression of human recombinant proteins of interest that are modified post-translationally, for example, by glycosylation. Such proteins may have advantageous properties in comparison with their counterparts produced in non-human systems such as Chinese Hamster Ovary cells.


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