The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2005
Filed:
Dec. 20, 2002
Satyam Nampalli, Belle Mead, NJ (US);
Weihong Zhang, Highland Park, NJ (US);
Sudhakar Rao, Belle Mead, NJ (US);
Shiv Kumar, Belle Mead, NJ (US);
Satyam Nampalli, Belle Mead, NJ (US);
Weihong Zhang, Highland Park, NJ (US);
Sudhakar Rao, Belle Mead, NJ (US);
Shiv Kumar, Belle Mead, NJ (US);
Amersham Biosciences Corp, Piscataway, NJ (US);
Abstract
Exploitation of suitably functionalized heterocyclic molecules, in the design and synthesis of Fluorescence Resonance Energy Transfer (FRET) cassettes and their corresponding dideoxynucleotide terminators culminated into efficient reagents for DNA sequencing. Additionally, these FRET cassettes/terminators, of the present invention, derived from different classes of heterocyclic systems have high potential to be used for general labelling of biological molecules to generate highly sensitized signals. Their preparation, energy transfer efficiency, and use as labels, specifically, in DNA sequencing reactions is disclosed.