The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 08, 2005
Filed:
Mar. 29, 2000
Caroline J. Springer, Surrey, GB;
Lawrence C. Davies, Surrey, GB;
Caroline J. Springer, Surrey, GB;
Lawrence C. Davies, Surrey, GB;
Cancer Research Campaign Technology Limited, London, GB;
Abstract
This invention pertains to nitrogen mustard compounds (Formula (II)) and prodrugs therefor (Formula (I)), methods for their preparation, pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in therapy and treatment, for example, of cancer, wherein: Rand Rare independently —Cl, —Br, —I, —OSOCH, or —OSOPh; R, R, R, and Rare independently —H, a Calkyl group, or a Chaloalkyl group; Ris —F, —Cl, —Br, —I, —OCHF, —C≡CH, —OCF, —CH, —CF, —SF, —SCF, or —CFCF; Ris —H or as defined for R, Ris —H or —F; Ris —H, —C(CH), or —CH—CH—CH; Z is —CH—T—W; T is —CH—, —O—, —S—, —(S═O)—, or —(SO)—; W is one of: (1) —COOH; (2)—(C═O)OR; (3) —(C═O)NRR; (4) —SONHR, (5) SOOR; (6)—PORR; (7) a tetrazol-5-yl group; (8) —CONH—SOR; and, (9)-M-Het.