The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 08, 2005
Filed:
Jun. 08, 1999
Christophe Alain Thurieau, Paris, FR;
Lydie Francine Poitout, Paris, FR;
Marie-odile Galcera, Bondoufle, FR;
Christophe Philippe Moinet, Chatenay Malabry, FR;
Thomas D. Gordon, Medway, MA (US);
Barry A. Morgan, Franklin, MA (US);
Christophe Alain Thurieau, Paris, FR;
Lydie Francine Poitout, Paris, FR;
Marie-Odile Galcera, Bondoufle, FR;
Christophe Philippe Moinet, Chatenay Malabry, FR;
Thomas D. Gordon, Medway, MA (US);
Barry A. Morgan, Franklin, MA (US);
Abstract
The present invention is directed to imidazolyl derivatives of the formula:where the substituents are defined in the specification, or a pharmaceutically acceptable salt thereof. The derivatives bind selectively to the somatostatin subtype receptors and elicit either an agonist or antagonist effect from the somatostatin subtype receptors. The derivatives are useful for treating a variety of diseases including acromegaly, restenosis, Crohn's disease, systemic sclerosis, external and internal pancreatic pseudocysts and ascites, VIPoma, nesidoblastosis, hyperinsulinism, gastrinoma, Zollinger-Ellison Syndrome, diarrhea, AIDS related diarrhea, chemotherapy related diarrhea, scleroderma, Irritable Bowel Syndrome, pancreatitis, small bowel obstruction, gastroesophageal reflux, duodenogastric reflux, Cushing's Syndrome, gonadotropinoma, hyperparathyroidism, Graves' Disease, diabetic neuropathy, Paget's disease, polycystic ovary disease, cancer, cancer cachexia, hypotension, postprandial hypotension, panic attacks, GH secreting adenomas or TSH secreting adenomas.