The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 08, 2005
Filed:
Nov. 19, 2002
Frederick Earl Boyer, Jr., Canton Township, MI (US);
John Michael Domagala, Canton, MI (US);
Edmund Lee Ellsworth, Brighton, MI (US);
Christopher Andrew Gajda, Ann Arbor, MI (US);
Susan Elizabeth Hagen, Canton Township, MI (US);
Michael James Lovdahl, Ann Arbor, MI (US);
Elizabeth Ann Lunney, Ann Arbor, MI (US);
Larry James Markoski, Champaign, IL (US);
Josyula Venkata Nagendra Vara Prasad, Ann Arbor, MI (US);
Bradley Dean Tait, Canton, MI (US);
Frederick Earl Boyer, Jr., Canton Township, MI (US);
John Michael Domagala, Canton, MI (US);
Edmund Lee Ellsworth, Brighton, MI (US);
Christopher Andrew Gajda, Ann Arbor, MI (US);
Susan Elizabeth Hagen, Canton Township, MI (US);
Michael James Lovdahl, Ann Arbor, MI (US);
Elizabeth Ann Lunney, Ann Arbor, MI (US);
Larry James Markoski, Champaign, IL (US);
Josyula Venkata Nagendra Vara Prasad, Ann Arbor, MI (US);
Bradley Dean Tait, Canton, MI (US);
Agouron Pharmaceuticals, Inc., San Diego, CA (US);
Abstract
The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.