The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2005
Filed:
Nov. 13, 2002
Marina Yu Etinger, Nesher, IL;
Lev M. Yudovich, Haifa, IL;
Michael Yuzefovich, Haifa, IL;
Gennady A. Nisnevich, Haifa, IL;
Ben Zion Dolitzky, Petach-Tiqva, IL;
Boris Pertsikov, Nesher, IL;
Boris Tishin, Haifa, IL;
Dina Blasberger, Raanana, IL;
Marina Yu Etinger, Nesher, IL;
Lev M. Yudovich, Haifa, IL;
Michael Yuzefovich, Haifa, IL;
Gennady A. Nisnevich, Haifa, IL;
Ben Zion Dolitzky, Petach-Tiqva, IL;
Boris Pertsikov, Nesher, IL;
Boris Tishin, Haifa, IL;
Dina Blasberger, Raanana, IL;
Teva Pharmaceutical Industries Ltd., Petah Tiqva, IL;
Abstract
The present invention relates to protected valacyclovir, N-tert-butoxycarbonyl-L-valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy] ethyl ester, and a method of making it. The present invention further relates to a method of making valacyclovir including the steps of coupling an amine protected valine selected from N-t-butoxycarbonyl valine and N-formyl valine with acyclovir using a coupling agent to form a protected valacyclovir, and deprotecting the protected valacyclovir to form valacyclovir or a pharmaceutically acceptable salt thereof. The present invention further relates to valacyclovir in pure form, a method of making pure valacyclovir, and to compositions containing pure valacyclovir.