The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2005
Filed:
Aug. 18, 2000
Michael Shin-san Su, Newton, MA (US);
Ted Fox, Maynard, MA (US);
Keith Philip Wilson, Boston, MA (US);
Ursula A. Germann, Newton, MA (US);
Michael Shin-San Su, Newton, MA (US);
Ted Fox, Maynard, MA (US);
Keith Philip Wilson, Boston, MA (US);
Ursula A. Germann, Newton, MA (US);
Vertex Pharmaceuticals Incorporated, Cambridge, MA (US);
Abstract
The invention relates to methods for designing inhibitors of serine/threonine kinases and tyrosine kinases, particularly MAP kinases, through the use of ATP-binding site mutants of those kinases. The methods of this invention take advantage of the fact that the mutant kinases are capable of binding inhibitory compounds of other kinases with greater affinity than the corresponding wild-type kinase. The invention further relates to the mutant kinases themselves and crystallizable co-complexes of the mutant kinase and the inhibitory compound.