The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2005
Filed:
May. 17, 2000
Dominique P. Bridon, Outremont, CA;
Alan M. Ezrin, Moraga, CA (US);
Peter G. Milner, Los Altos Hills, CA (US);
Darren L. Holmes, Montreal, CA;
Karen Thibaudeau, Montreal, CA;
Dominique P. Bridon, Outremont, CA;
Alan M. Ezrin, Moraga, CA (US);
Peter G. Milner, Los Altos Hills, CA (US);
Darren L. Holmes, Montreal, CA;
Karen Thibaudeau, Montreal, CA;
ConjuChem, Inc., Montreal, CA;
Abstract
A method of synthesizing a modified therapeutic peptide capable of forming a peptidase-stabilized therapeutic peptide conjugate, the peptide having between 3 and 50 amino acids, is k. In a first step of the method, a therapeutic peptide having a carboxy terminal amino acid and amino terminal amino acid is synthesized. In a second step, pairs of cysteine residues present in the therapeutic peptide are sequentially and selectively oxidized to form disulfide bridges in the therapeutic peptide. In a third step, a protecting group is attached to remaining cysteine residues that do not form disulfide bridges in the therapeutic peptide. Finally, the peptide is coupled to a reactive group capable of reacting with amino groups, hydroxyl groups or thiol groups on a blood component to form a covalent bond therewith.