The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2005
Filed:
Feb. 16, 1999
Ilan Ziv, Kfar-Sava, IL;
Anat Shirvan, Herzliya, IL;
Ilan Ziv, Kfar-Sava, IL;
Anat Shirvan, Herzliya, IL;
Abstract
The present invention relates to an isolated and purified peptide of the RY domain having an amino acid sequence of general formula (I) comprising a sequence of the following amino acids: X—X—X—X—X—X—X—X—X, X=Phe, Tyr, or any amino acid having a substituted aromatic residue; X=Glu, Asp, Ser, or any amino acid having a —(CH)—COO residue, wherein n=0-3; X=Asp, Thr, any aliphatic amino acid, or any of amino acids X; and X=Arg, Lys, or any amino acid having a —(CH)—NHresidue, or a —(CH)—NH—C(NH)NHresidue wherein n=0-4; as well as functional equivalents thereof. The invention relates also to pharmaceutical compositions comprising a compound of general formula (I), the use of said RY peptide and of said pharmaceutical composition in the preparation of a medicament and in method for the treatment of disorders of inappropriate activation of apoptosis; for increasing the number of viable cells in a biological tissue; and in a method for the enhancement for the survival of biological cells. The invention also relates to a method for the preparation of a RY-peptide of general formula (I). Furthermore, the invention also relates to an in vitro assay system for the regulation of cell death by the Bcl-2 family of test compounds (as hereinbefore defined).