The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2005
Filed:
Apr. 03, 2001
Michael A. Innis, Moraga, CA (US);
Christoph J. Reinhard, Alameda, CA (US);
Ronald N. Zuckermann, El Cerrito, CA (US);
Michael A. Innis, Moraga, CA (US);
Christoph J. Reinhard, Alameda, CA (US);
Ronald N. Zuckermann, El Cerrito, CA (US);
Chiron Corporation, Emeryville, CA (US);
Abstract
Chimeric oligonucleotide of the formula 5'-W—X—Y—X—Z-3′, where W represents a 5′-O-alkyl nucleotide, each of Xand Xrepresents a block of seven to twelve phosphodiester-linked 2′-O-alkyl ribonucleotides, Y represents a block of five to twelve phosphorothioate-linked deoxyribonucleotides, and Z represents a blocking group effective to block nuclease activity at the 3′ end of the oligonucleotide, are described. These compounds exhibit high resistance to endo- and exonucleases, high sequence specificity, and the ability to activate RNAse H, as evidenced by efficient and long-lasting suppression of target mRNA. The oligonucleotides are preferably transfected into cells in formulations containing a lipid-peptoid conjugate carrier molecule of the formulaL-linker-[N(CHCHNH)CH(C═O)—N(CHCHR)CH(C═O)—N(CHCHR)CH(C═O)]—NH,where L is a lipid moiety, including a steroid, and each group R is independently selected from alkyl, aminoalkyl, and aralkyl.