The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2005
Filed:
Jul. 15, 2002
Peter Angel, Leimeu, DE;
Norbert Fusenig, Heidelberg, DE;
Andrea Kolbus, Rastatt, DE;
Marina Schorpp-kistner, Durmersheim, DE;
Axel Szabowski, Heldelberg, DE;
Nicole Maas-szabowski, Heidelberg, DE;
Sven Andrecht, Darmstadt, DE;
Peter Angel, Leimeu, DE;
Norbert Fusenig, Heidelberg, DE;
Andrea Kolbus, Rastatt, DE;
Marina Schorpp-Kistner, Durmersheim, DE;
Axel Szabowski, Heldelberg, DE;
Nicole Maas-Szabowski, Heidelberg, DE;
Sven Andrecht, Darmstadt, DE;
Deutsche Krebsforschungszentrum Stiftung des Offentlichen rechts, Heidelberg, DE;
Abstract
The invention relates to genetically modified fibroblast cells which comprise the following properties: (a) a gene, encoding a subunit of the transcription factor AP-1, of its genome is inactivated and/or a component, acting on the AP-1 transcription factor of the signal transduction pathway is modified resulting in a modified AP-1 activity; (b) functionally linked with a promoter, it contains in an expression vector the gene from (a) in a form such that the active subunit is only expressed after induction of the promoter or the subunit encoded by the gene is present in inactive form and a form that can be activated. Furthermore, the invention relates to a method which uses the fibroblast cell according to the invention to identify a compound which can support, inhibit or modify the AP-1-dependent differentiation and/or proliferation of keratinocytes or a gene which is involved in the AP-1-dependent differentiation and/or proliferation of keratinocytes as well as to the use of the test compound identified according to the method of the invention and the gene for treating or diagnosing diseases associated with a disturbed proliferation and/or differentiation of keratinocytes.