The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2005
Filed:
May. 13, 1999
William S. Argraves, Charleston, SC (US);
Samar Hammad, Charleston, SC (US);
Steingrimur Stefansson, Gaithersburg, MD (US);
Bryan Brewer, North Bethesda, MD (US);
Alan Remaley, Bethesda, MD (US);
William S. Argraves, Charleston, SC (US);
Samar Hammad, Charleston, SC (US);
Steingrimur Stefansson, Gaithersburg, MD (US);
Bryan Brewer, North Bethesda, MD (US);
Alan Remaley, Bethesda, MD (US);
American National Red Cross, Falls Church, VA (US);
The United States of America as represented by the Department of Health and Human Services, Washington, DC (US);
MUSC Foundation for Research Development, Charleston, SC (US);
Abstract
The present invention provides an isolated mammalian receptor which specifically binds a high density lipoprotein holoparticle, comprising a subunit of approximately 45-600 kDa molecular weight and one or more subunits selected from the group consisting of a subunit of approximately 40-50 kDa molecular weight, a subunit of approximately 120 kDa molecular weight and a subunit of approximately 400 kDa molecular weight. In addition, the present invention provides a method of screening a substance for the ability to modulate the HDL holoparticle binding and/or internalization activity of the receptor of this invention, comprising: a) contacting the substance with a cell producing a functional HDL receptor; and b) assaying the cell for a modulation of the HDL holoparticle binding and/or internalization activity of the receptor, whereby a modulation of the HDL holoparticle binding and/or internalization activity of the receptor identifies a substance with the ability to modulate the HDL holoparticle binding and/or internalization activity of the ADL receptor.