The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2005
Filed:
Jan. 06, 2000
Nathalie Marie-josephe Claude Garcon, Wavre, BE;
Martin Friede, Brussels, BE;
Nathalie Marie-Josephe Claude Garcon, Wavre, BE;
Martin Friede, Brussels, BE;
SmithKline Beecham Biologicals s.a., Rixensart, BE;
Abstract
A novel adjuvant composition comprising a sterol (e.g., cholesterol, β-sitosterol, stigmasterol, ergosterol, and ergocalciferol) and saponin fraction (e.g., QSalso known as QA) in the form of an immunostimulating complex, or ISCOM, is disclosed. QSis an immunologically active saponin fraction having adjuvant activity derived from the bark of Quillaja Saponaria Molina. Previous attempts in the prior art to prepare ISCOMs comprising QSwere unsuccessful. Thus, the instant application discloses the first successful attempt to prepare ISCOMs comprising purified QSSmall unilamelar liposomes containing cholesterol, in the absence of any detergent, were prepared, followed by the addition of an aqueous solution of QSThe claimed compositions will prove useful in the preparation of highly immunogenic vaccine compositions.