The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 25, 2005
Filed:
Feb. 04, 2000
Jacek Gaertig, Athens, GA (US);
Harry W. Dickerson, Jr., Athens, GA (US);
Theodore G. Clark, Ithaca, NY (US);
Jacek Gaertig, Athens, GA (US);
Harry W. Dickerson, Jr., Athens, GA (US);
Theodore G. Clark, Ithaca, NY (US);
University of Georgia Research Foundation, Inc., Athens, GA (US);
Abstract
The ciliated protozoan Tetrahymena exemplifies a recombinant system for the expression of heterologous nucleic acids, preferably on the plasma membrane surface. Integration of a heterlogous nucleic acid into the β-tubulin gene, BTU1, of a paclitaxel-sensitivemutant that possesses btu1-1K350M β-tubulin allele allows screening for transformants using negative selection, as transformants have restored paclitaxel resistance. Transgenic ciliated protozoa of the invention can serve as live vaccines. For example, transgenic Tetrahymena expressingi-antigen protein on their surface are effective vehicles for vaccination of freshwater fish against infection by