The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 18, 2005

Filed:

Sep. 11, 2000
Applicants:

Wolfgang Pfleiderer, Constance, DE;

Harald Schmidt, Giessen, DE;

Lothar Fröhlich, Würzburg, DE;

Peter Kotsonis, Würzburg, DE;

Shahriyar Taghavi-moghadam, Mainz, DE;

Inventors:

Wolfgang Pfleiderer, Constance, DE;

Harald Schmidt, Giessen, DE;

Lothar Fröhlich, Würzburg, DE;

Peter Kotsonis, Würzburg, DE;

Shahriyar Taghavi-Moghadam, Mainz, DE;

Assignee:

Vasopharm Biotech GmbH, Wurzburg, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 314985 ; C07D47508 ;
U.S. Cl.
CPC ...
Abstract

Compounds of formula (I), where preferably: A=a bridge of partial formula (II) or (III), Rand R=independently (substituted) alkyl, aryl or aralkyl, or together form a heterocycle, R=H, —CO-Alkyl, or —CO-Aryl, R=Aryl, —CO—O-Aryl or —CO-Aryl and R=H, are potent inhibitors of NO-synthase and are suitable as pharmaceutical agents of prophylaxis and treatment of disease states associates with a disturbed NO metabolism.


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