The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 11, 2005
Filed:
Mar. 31, 2003
David M. Lucas, Hilliard, OH (US);
Mark R. Parthun, Hilliard, OH (US);
John C. Byrd, Columbus, OH (US);
Michael R. Grever, Columbus, OH (US);
David M. Lucas, Hilliard, OH (US);
Mark R. Parthun, Hilliard, OH (US);
John C. Byrd, Columbus, OH (US);
Michael R. Grever, Columbus, OH (US);
The Ohio State University, Columbus, OH (US);
Abstract
The invention provides methods for treating a patient with chronic lymphocytic leukemia of B cells (B-CLL). One method comprises administering to a patient with B-CLL, one or more benzamide derivatives, the benzamide derivatives including MS-275 and related compounds. Another method comprises administering to a patient with B-CLL, one or more of the benzamide derivatives, and additionally administering to the patient one or more antibodies immunospecific for 1D10 antigen. Additional methods for inducing apoptosis of B-CLL cells and for increasing expression of 1D10 antigen in B-CLL cells using the benzamide derivatives are also provided.