Quinolylpropylpiperidine derivatives, intermediates and compositions containing them, and preparation therefor

Abstract

Quinolylpropylpiperidine derivatives of general formula (I) in which Ris hydrogen, halogen, hydroxyl, amino, alkylamino, dialkylamino, hydroxyamino, alkoxyamino or alkylalkoxyamino and Ris hydrogen, or Rand Rform an oxo, Ris carboxyl, carboxymethyl or hydroxymethyl, Ris alkyl either substituted with phenylthio optionally substituted with halogen, hydroxyl, alkyl, alkoxy, trifluoromethyl, trifluoromethoxy, carboxyl, alkoxycarbonyl, cyano or amino, or with cycloalkylthio (3 to 7 members) optionally substituted with halogen or trifluoromethyl, or with heteroarylthio (5 to 6 members and 1 to 4 heteroatoms chosen from N, O and S), optionally substituted with halogen, hydroxyl, alkyl, alkoxy, trifluoromethyl, trifluoromethoxy, carboxyl, alkoxycarbonyl, cyano or amino or Ris propargyl substituted with phenyl or heteroaryl as defined above, Ris alkyl, alkenyl-CH— or alkynyl-CH—, cycloalkyl or cycloalkylalkyl, in their various isomeric forms, separate or as mixtures, and also their salts, their preparation process and intermediates and the compositions containing them. These novel derivatives are potent antibacterial agents.