The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 11, 2005
Filed:
Jul. 26, 2001
Applicants:
Rolf Müller, Marburg, DE;
Roland E. Kontermann, Marburg, DE;
Silvia Montigiani, Siena, IT;
Inventors:
Assignee:
Topotarget UK Limited, Abingdon, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 502 ; C07K 700 ; C07K 1400 ; C07K 14435 ; C07K 1900 ; A61K 3900 ;
U.S. Cl.
CPC ...
Abstract
The present invention provides peptides which bind to the DNA binding domain of transcription factor E2F, and inhibit cell cycle progression. Peptides include FWLRFT (SEQ ID NO:1); WVRWHF (SEQ ID NO:2); WHFIFW (SEQ ID NO:3); IWLSGLSRGVWVSFP (SEQ ID NO:4); and GSRILTFRSGSWYAS (SEQ ID NO:5) and derivatives based upon these sequences. Compositions and the use of the peptides in inhibiting cell cycle progression, such as in uncontrolled cell proliferation, are also provided.